Maternal endocrine disorders will lead to abortion, such as luteal dysfunction, polycystic ovary, etc., the specific distribution is as follows:
(1) luteal dysfunction accounted for 23% ~ 60%, and luteal progesterone in luteal phase was lower than 15ng/ml, resulting in adverse reaction to the decidual membrane of pregnancy. Luteal dysfunction could only be included in the diagnosis if luteal function was not detected in 2 ~ 3 cycles. Luteal dysfunction affected egg implantation.
(2) the high concentration of luteinizing hormone, high androgen and hyperinsulinemia in polycystic ovary syndrome (pcos) reduces the quality of eggs and endometrial receptivity, which may easily lead to abortion. If polycystic ovary is amalgamated with uterine mediastinum, affect fetal growth and development.
(3) there are prolactin receptors in luteal cells of hyperprolactinemia, which inhibit the lutein of granulosa cells and steroid hormones, leading to luteal dysfunction and decreased egg quality.
(4) thyroid disease hypothyroidism is associated with recurrent spontaneous abortions.
(5) subclinical or well-controlled diabetes mellitus will not lead to abortion, and the rate of spontaneous abortion of uncontrolled insulin-dependent diabetes mellitus will increase.